The surgery — which will take 100 surgeons 36 hours, and cost $12.6 million — will be performed on a computer scientist from Russia who suffers from muscular dystrophy, says Ranu Joardar
Imagine that it’s the 1970s or 80s and top neuroscientists declared that human head transplant is possible. Everybody would have laughed it off. Here we are knocking at 2016, and human head transplant looks possible with a project code-named HEAVEN/GEMINI.
For several years we have limited our dreams to see xenotransplantation (replacing a human organ/body part with an animal’s part) become a success. Mythology has stories where God breathed life into a dead body by doing xenotransplantation, like in the case of Lord Ganesha and King Daksha.
In 1996, the dream of transposing one’s head with another was depicted in Tim Burton directed American comic science movie Mars Attacks! The film has a scene where Mars inhabitants transpose a journalist’s head with her pet’s body. Of course, this scene made many laugh their heads off! Some scientists, in fact, dared to make it possible by conducting such operations — all of which failed.
Well now we can let go of xenotransplantation as come 2017 and we may see head transplantation. Recently a Chinese professor of Harbin Medical University, Ren Xiaoping, along with Italian neurosurgeon Sergio Canavero, announced that they will be conducting a surgery wherein they will put a person’s head onto another person’s body in December 2017.
Head transplants, or body transplants depending on how you look at them, are not just a thing of quirky horror movies. In as little as two years’ time, a new chapter may be added to the medical history if the human head transplant becomes a success.
Xiaoping and Canavero have started working hard toward making the seemingly impossible thing possible. With the declaration of this mind blowing surgery, Canavero has also earned the name of Dr Frankenstein.
The surgical procedure is called Allogeneic Head and Body Reconstruction. It involves transplanting a healthy human body, most likely donated by a brain dead person, to a person with a healthy brain and damaged body. However, many researchers are apprehensive about the success of this surgery.
Dr Li Wei, a transplant surgeon at the General Hospital of Armed Police Forces in Beijing, has been quotes as saying that this surgery is too good to be true. He said a number of technical problems arise with such a procedure. Li claims that at present it is impossible to do the necessary repairs on damaged spinal nerves. The transplant also has to deal with a conjunction of neurons, blood vessels and muscles.
There are also ethical issues to deal with, such as the identities of patients. “Who will the person be after receiving the body of another?” pointed out Li Wei.
Like other doctors, Dr P Sarat Chandra, professor of AIIMS neurosurgery, also feels that head transplant in the present situation seems impossible. But he says some ideas seem crazy at first but ultimately work out, and the head transplant might also become possible some day. “At present there is no known technology that can join the central nervous system. Spinal cord has two parts — an outer covering and a cord inside. Joining the cord is going to be a big issue. I would say it is not a challenge but there are a lot of question marks,” he said.
Dr Chandra adds, “Even if the surgery is successful and the patient is able to get off life support system, how long will he survive and will he regain the function of his hands and legs? The sense in the head may happen but the question is of the body.”
“If the patient, after getting the head, is able to get off the ventilator and lives for just four or five months, then also it will be a huge success as then further research will be done and more progress will be seen in future. But if the patient survives the period like any normal human being, then it won’t be less than a miracle, but I don’t expect that. However, even if it doesn’t work, it means we have started looking in that direction.”
The Allogeneic Head and Body Reconstruction surgery will be conducted on Valery Spiridonov. Spiridonov, a computer scientist from Russia suffering from muscular dystrophy, has agreed to become the first patient to undergo the surgery. The young man was diagnosed with a genetic muscle-wasting condition called Werdnig-Hoffman disease at an early age. Despite knowing the extreme risks of undergoing such a procedure, he has agreed as he is eager for a new, functioning body.
Speaking publicly about his decision, Valery was quoted as saying: “When I realised that I could participate in something really big and important, I had no doubt left in my mind and started to work in this direction... The only thing I feel is the sense of pleasant impatience, like I have been preparing for something important all my life and it is starting to happen.”
However, Xiaoping has stressed that the project is still at least two years away. It is crucial to assure proper funding and backing of technology and expert teams. “It is impossible to give an exact date as the conditions are not yet ready for clinical trials for the operation,” he said.
According to reports, the procedure would take 100 surgeons 36 hours, and would cost around $12.6 million.
According to a news report by AFP, in China, many do not donate organs due to belief in reincarnation, and has reached an impasse with its simultaneously high demand for and chronic shortages of organs — a void that death row inmates have controversially filled.
Contrary to these problems, China hugely supports the pathbreaking surgery. “China wants to do it because they want to win the Nobel Prize,” says Canavero. They want to prove themselves as a scientific powerhouse. So it’s the new space race.
Xiaoping says, “Right now, China wants to go to the top.” He adds that if there is a great benefit in research, China will put resources into it. If successful, the procedure would bring significant changes to humankind, and save patients whose bodies are in critical condition, he adds.
“If a man with an aging body can replace his body with a young and healthy body, his aging brain will become younger with the new body, meaning longer life for the man,” he said.
Canavero has said the procedure (head anastomosis venture) might be feasible — with improved technology and accurate ability to keep neural tissue perfused — before the end of 2017, which is when he and his team intend to perform the procedure either in the US or China.
Amid all these speculations, Spiridonov seems composed.
According to Canavero’s calculations, if everything goes according to the plan, two years is the timeframe needed to verify all scientific calculations and plan the procedure’s details. “It isn’t a race. No doubt, the surgery will be done once the doctor and the experts are 99 per cent sure of its success,” he said.
Well for now we can only wish the surgeons luck and hope that Spiridonov’s head gets a matching donor. Dr Chandra says this would be the most challenging thing — as in cases of organ donation, doctors can do trials, but in this case there is no time for trials — or else both the body and the head are going to get wasted and this surgery will stop for at least a few years.